Piperazine is an anthelmintic with activity against
nematodes. It induces a reversible flaccid paralysis
in the nematode parasites. This is provoked by
hyperpolarisation of the cell membrane followed by
suppression of spontaneous spike potentials. The
paralysed nematodes are subsequently expelled
from the gut lumen by normal peristaltic actions.
Nematode infections in horses, swine, cattle and
Strongylus, Oxyuris, Trichonema and Ascaris.
Oesophagostomum and Ascaris.
Ascaris, Nematodirus, Ostertagia, Cooperia and
Ascaris and Capillaria.
Hypersensitivity to piperazine.
Administration to animals with a seriously impaired
hepatic and/or renal function.
Overdoses can cause colic, coughing, excessive
salivation, excitation, hyperpnoea, lachrymation,
spasms, sweating and vomiting."